Let G be the graph with vertex set those pairs (x,y)∈N2 with
gcd(x,y)=1, in which we join two vertices if the differ in only one coordinate, and
there by ±1.
Is there a path going to infinity on G, say P, such that for all (x,y)∈P both
min(x,y)>1 and at least one of x or y is composite?
The weaker version (only min(x,y)>1) was solved by C. Stewart via the prime-pair path
(pk,pk+1)→(pk+1,pk+2), as recounted in [Er80]; the compositeness condition
forbids those anchors and the question is open.